Sympathetic α3β2‐nAChRs mediate cerebral neurogenic nitrergic vasodilation
نویسندگان
چکیده
منابع مشابه
Sympathetic α₃β₂-nAChRs mediate cerebral neurogenic nitrergic vasodilation in the swine.
The α(7)-nicotinic ACh receptor (α(7)-nAChR) on sympathetic neurons innervating basilar arteries of pigs crossed bred between Landrace and Yorkshire (LY) is known to mediate nicotine-induced, β-amyloid (Aβ)-sensitive nitrergic neurogenic vasodilation. Preliminary studies, however, demonstrated that nicotine-induced cerebral vasodilation in pigs crossbred among Landrace, Yorkshire, and Duroc (LY...
متن کاملAlpha7-nicotinic acetylcholine receptors on cerebral perivascular sympathetic nerves mediate choline-induced nitrergic neurogenic vasodilation.
It has been suggested in isolated porcine cerebral arteries that stimulation by nicotine of alpha7-nicotinic acetylcholine receptors (alpha7-nAChRs) on sympathetic nerves, but not direct stimulation of parasympathetic nitrergic nerves, caused nitrergic neurogenic dilation. Direct evidence supporting this hypothesis has not been presented. The present study, which used in vitro tissue bath and c...
متن کاملSympathetic 3 2-nAChRs mediate cerebral neurogenic nitrergic vasodilation in the swine
Reggie Hui-Chao Lee, Yi-Qing Liu, Po-Yi Chen, Chin-Hung Liu, Mei-Fang Chen, Hung-Wen Lin, Jon-Son Kuo, Louis S. Premkumar, and Tony Jer-Fu Lee Institutes of Medical Sciences and Pharmacology and Toxicology, College of Medicine; Institute of Life Sciences and Center for Vascular Medicine, College of Life Sciences, Tzu Chi University; Department of Research, Buddhist Tzu Chi General Hospital, Hua...
متن کامل7-Nicotinic Acetylcholine Receptors on Cerebral Perivascular Sympathetic Nerves Mediate Choline-Induced Nitrergic Neurogenic Vasodilation
It has been suggested in isolated porcine cerebral arteries that stimulation by nicotine of 7-nicotinic acetylcholine receptors ( 7-nAChRs) on sympathetic nerves, but not direct stimulation of parasympathetic nitrergic nerves, caused nitrergic neurogenic dilation. Direct evidence supporting this hypothesis has not been presented. The present study, which used in vitro tissue bath and confocal m...
متن کاملPresynaptic prostaglandin E2 EP1-receptor facilitation of cerebral nitrergic neurogenic vasodilation.
BACKGROUND AND PURPOSE Prostaglandin E(2) (PGE(2)) modulates autonomic transmission in the peripheral circulation. We investigated the role of endogenous PGE(2) and its presynaptic EP(1) receptor subtype in modulating the autonomic neurotransmission in cerebral vasculature. METHODS The standard in vitro tissue-bath technique was used for measuring changes in isolated porcine basilar arterial ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.932.15